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A hidden Markov model is integrated into the SPINDLE scoring process to help to define the dynamics of vigilance states and suppress physiologically implausible sleep transitions

doi: 10.14336/AD.2020.0912

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The 45-degree injection angle for subcutaneous administration ensures the medication deposits in the fatty tissue layer rather than going too deep into muscle or too shallow into the skin

Evidence for specific clinical outcomes is still evolving, and individual results vary