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Vitamin B12 injections should always be prescribed by a doctor, who can advise the dose, frequency of application and treatment duration, all which vary depending on the condition being treated

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Other factors include: Underlying cause of deficiency : Pernicious anaemia, malabsorption disorders, or dietary insufficiency may affect treatment response Medication use : Metformin and proton pump inhibitors can reduce gastrointestinal B12 absorption (though this does not affect the efficacy of intramuscular injections) Individual variation : Differences in how efficiently your body utilises the injected vitamin Adherence to treatment schedule : Missing injections or delaying maintenance doses can slow recovery Discussing these factors with your healthcare provider helps set realistic expectations for your treatment journey

BMJ 2021:372

This was due to increased plasma glycerol levels (which is an indicator of lipolysis) and in vivo fat oxidation