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Its synthesised by bacteria in the gut of animals and when we eat animal products we ingest it as a byproduct
PMID: 41524160 Adv Sci (Weinh) Piezo1 Upregulation in Monocyte-Derived Macrophages Impairs Post-Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis
doi: 10.1021/acs.jafc.2c03099 Summary Keywords gut microbiome, TMAO, kidney injury, chronic kidney disease, end-stage renal disease, inflammatory mechanisms Citation Su J-Q, Wu X-Q, Wang Q, Xie B-Y, Xiao C-Y, Su H-Y, Tang J-X and Yao C-W (2025) The microbial metabolite trimethylamine N-oxide and the kidney diseases
Injury or trauma : Following trauma to your thyroid (such as neck injury, thyroid cancer treatment, or surgery), your thyroid gland may get damaged, leading to hypothyroidism
(2020) found that ferroptosis inducer Ras-selective lethal small molecule 3 treatment exacerbated the disease symptom, including hepatic steatosis and inflammation, which could be restored by the intervention of ferroptosis inhibitors
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