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Enduring effects of nicotine in adolescence on adult cholinergic signaling Acetylcholine acts as a neuromodulator in the brain, where it signals through cationic nAChRs and metabotropic muscarinic receptors, notably regulating cellular excitability, synaptic plasticity, and the coordinated firing of groups of neurons to play a key role in fundamental aspects of brain physiology including emotion, cognition and motivation [100]

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