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Methotrexate-polyglutamate stimulates pro-inflammatory cytokines, such as TNF-, IL-6, and nuclear factor- B (NF-B), initiating inflammatory reactions that damage hepatocytes

This mechanism establishes hADSC-Exos as a viable cell-free regenerative therapy for POF, offering benefits such as low immunogenicity and enhanced safety compared to direct stem cell transplantation (Huang et al

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Diagnostic delay for endometriosis in Austria and Germany: Causes and possible consequences