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Injections have better bioavailability than oral supplements as they bypass the digestive system completely, providing a direct supply of B12 into the bloodstream to fuel your body

What your describing is not uncommon because methylation process is so complex & you may be deficient in other co-factors, such as B6, B2, Same, B12, etc Too much 5MTHF can drive overmethylation or dampen glutathione production and lead to agitation, irritability

Doshi et al

U54HD061221), which is a part of the National Institutes of Health (NIH) Rare Disease Clinical Research Network (RDCRN), supported through collaboration between the Office of Rare Diseases Research (ORDR), the National Center for Advancing Translational Science (NCATS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and NIH K08DK106453

Peder Larson Room 5 - Topic: Neuroimaging Moderators: Drs