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Introduction Glutathione is becoming a widely popular skincare ingredient for brighter skin and even skin tone due to its antioxidant properties

However, the translation of these CAF-targeted therapies into clinical interventions has proven challenging and has not been as successful as anticipated

Dings MPG, Manoukian P, Waasdorp C, Quik JSE, Strijker M, Lodestijn SC, et al

Red blood cell glutathione measurement is most reliable

For example, Chinese formulations such as Xiaoyaosan and Danzhi-Xiaoyao-San have demonstrated the ability to regulate gut microbiota in animal models, leading to improved depressive behaviors