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Zonulin was originally identified as pre-haptoglobin-2, a protein that modulates both the intestinal barrier and the blood-brain barrier by disassembling tight junctions

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Note, for BPC 157, a persistent effect is mandatory, as it can prevent amphetamine disturbances, reverse already advanced disturbances, and counteract amphetamine reverse tolerance even after a very long period (i.e., 46 days) [70,153] and even substitute the loss of dopamine neurons (MPTP) (note, BPC 157 counteracted tremor, rigor, akinesia, and also MPTP-mortality) [69]

The mechanisms do not overlap or interfere with each other