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In addition, hypoxia signaling has a significant impact on the Notch1 and HIF-1 signaling pathways, which influence each other and participate in physiological and pathological processes related to hypoxia, such as angiogenesis and tumor metastasis [509, 510]
Lastly, intrajejunal continuous infusion provides a greater systemic bioavailability of LDopa compared to the same equivalent oral daily dose
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