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Safety: What is and is not known Animal safety data A 2020 preclinical safety evaluation by Xu and colleagues in Regulatory Toxicology and Pharmacology examined BPC-157 across multiple species mice, rats, rabbits, and dogs and reported no serious toxicity, no genotoxicity, and no embryotoxicity at doses evaluated

Observations vary depending on study duration, exposure frequency, and tissue focus

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The toxins themselves can interfere with excretion into the urine, and thus in some cases provocation initially with glutathione for 7 days, and then some form of sauna / hot bath the evening prior to the first morning urine can be useful

Topical Treatments: Products containing urea, lactic acid, or salicylic acid can help dissolve the keratin buildup