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Zinc plays a critical role in maintaining endothelial health by supporting nitric oxide synthesis through the activation of endothelial nitric oxide synthase (eNOS), which is essential for vascular relaxation and anti-atherogenic effects [463]

Hypertension disrupts the normal function of cerebral blood vessels, promoting vascular A deposition, which, in turn, impairs vessel function, forming a vicious circle and eventually leads to cognitive dysfunction 2, 3

Interestingly, the combination of l-ARG supplementation with different substances, namely PDE5i, has been reported to induce a greater improvement in penile erectile function, compared to single compounds [16, 17]

Suchdev, Hubert Department of Global Health, Rollins School of Public Health, Atlanta, GA, USA