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these are mainly within the peritoneal cavity but have also been found, although rarely, in tissues including the brain, liver and lungs
The potential mechanisms were found to be related to regulating neurotransmitter (5-Hydroxytryptamine) and inflammatory factor levels, and importantly, blocking the JAK2/STAT3 signaling pathway effectively alleviated depressive symptoms in BC combined with depression mice, inhibiting tumor progression (Kumar and Roy, 2023)
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In fact, major depression is a common side effect of this disease: one study indicated that over 20% of the pancreatitis patients suffering from constant, severe pain reported using antidepressants to manage their depression concomitant to pain [14]
