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Mutations in EGFR and EML4-ALK occur more commonly in never-smokers or light smokers enabling targeted therapy with tyrosine kinase inhibitors and crizotinib respectively

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This protocol is reported in accordance with the Standard for Reporting Interventions in Clinical Trials of Acupuncture recommendations (STRICTA) ( Figure 1 Patients Smokers have the intention to quit smoking and meet our following criteria will be recruited at three sites simultaneously