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A systematic review analyzing zinc supplementation in PCOS found that doses ranging from 4 to 50 mg daily for 8 to 12 weeks resulted in improvements in insulin resistance (HOMA-IR) and lipid profiles while also reducing inflammatory markers such as hs-CRP and oxidative stress markers like malondialdehyde (MDA) and TAC [153]

Occludin is thought to be transcriptionally regulated, as measured by significant differences in mRNA levels between EC types

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FIGURE 3 TPPU and DHA + TPPU Decrease Inflammation in the Hippocampus of Diabetic Rats An increase in the neuroinflammation was evident in the hippocampus of diabetic rats due to the rise in the level of pro-inflammatory marker IL-1 (Figure 4A) (412 29 pg/ml) and IL-6 (Figure 4B) (180 6 pg/ml) and decrease in the level of anti-inflammatory marker IL-10 (Figure 4C) (220 7 pg/ml) in comparison to the healthy normal rats (IL-1, 311 14 pg/ml

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