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We think a better approach might be factors that interfere with the deleterious TNF signaling, which induces the profound inflammation in the kidneys, without interfering with TNFs defense role against bacteria, Lucas says

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COX-1 is often thought of as the physiologic housekeeper for many activities including vascular homeostasis, maintenance of renal and gastrointestinal blood flow, renal function, intestinal mucosal proliferation, platelet function, and antithrombogenesis

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For instance, AuNPs could be functionalized with drugs or targeting molecules and used for targeted delivery of drugs or as contrast agents for imaging