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Liu R, Kang JD, Sartor RB, Sikaroodi M, Fagan A, Gavis EA, et al

At the dawn of the transcriptomic medicine

Analytical investigation: Assay of D-lactate in diabetic plasma and urine

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found that the senescence-accelerated mouse prone 8 exhibits typical features of sarcopenia at 40 weeks of age, but the decrement of genes involved in mitochondrial biogenesis (PGC-1, NRF-1, TFAM, Ndufs8, and Cox5b) and mitochondrial dynamics fission (Mfn2 and Opa1) and autophagic flux are impaired from week 24, suggesting that early alterations of mitochondrial quality control and autophagic flux worsen muscle microenvironment prior to the onset of sarcopenia