[229] A study from Erasmus University Rotterdam limited to people with chronic obstructive pulmonary disease found that the cost-effectiveness of minimal counselling, intensive counselling, and drug therapy were 16,900, 8,200, and 2,400 per QALY gained respectively
People experience everything from night sweats and insomnia to increased irritability and mood swings, fierce cravings, and fatigue
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I did find out that it was roughly 1970 when it first appeared, and by the mid 70s it remained modestly popular