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Statins enhance NO bioavailability by decreasing NADPH oxidase activity in a Rac1-dependent manner, reducing caveolin-1 activity, decreasing asymmetric dimethyl-l-arginine, improving activating eNOS phosphorylation, and upregulating eNOS mRNA (196)

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Ethics declarations Conflict of interest This research has no known conflict of financial interests or personal relationships that could have appeared to influence the work reported in this paper

To be fully transparent, one thing that shows up in independent ingredient reviews is the small amount of ethanol in the formula, which is flagged for caution on its own, though here it's used in a tiny quantity as a natural preservative and carrier, not as a primary ingredient

Rannou et al