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GH releasing hormone (GHRH) has been shown to potentiate the ACTH and cortisol response to insulin-induced hypoglycemia, but not to potentiate the ACTH and cortisol response after administration of CRH/AVP (114)

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Without purification, Compounds F and G directly undergo a condensation reaction in the presence of a condensing agent and organic base to obtain the diimidazolodiazepine compound described in formula (refer to Fig

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