Consequently, loss of FMRP results in an aberrantly increased mGluRI expression in these neurons, leading to enhanced mGluR-related long-term depression causing cognitive impairments and intellectual disability
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This metabolic reprogramming led to mitochondrial membrane depolarization, increased reactive oxygen species generation, induction of apoptosis, and cell-cycle arrest at the G 2 phase
Slightly dull, a bit dehydrated, and not as firm as usual