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The balance of pro-inflammatory and anti-inflammatory cytokines is a prerequisite for an immune defense to run smoothly, but also for the immune reaction to come to a standstill again

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Together, these data show that FOXO4-DRI potently and selectively reduces the viability of senescent cells by competing with FOXO4-p53 binding, thereby triggering release of active p53 to the cytosol and inducing cell-intrinsic apoptosis through Caspase-3/7

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