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John Guggenheim Foundation
It directly binds to oxidative compounds that damage cell membranes, DNA and energy production
Through membrane proteomics screening using biotin-labeled PROTAC probes, the team identified CD36 as a major binding partner of both CRBN- and VHL-based PROTACs, as well as several non-traditional small-molecule therapeutics such as rapamycin and doxorubicin
Potent analogues of somatostatin (peptide hormone consisting of 14 amino acids, found in cells of the pancreas as well as in hypothalamic and other gastrointestinal cells) including octreotide (sandostatin) have been developed for the treatment of acromegaly, gigantism, thyrotropinoma, diarrhea and flushing episodes associated with carcinoid syndrome, and diarrhea in patients with vasoactive intestinal peptide-secreting tumors (VIPomas) [33]
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