Many individuals seek B12 for its positive effects on mood and general mental well-being
Table of Contents Symptoms of Vitamin B12 Deficiency In the absence of sufficient absorption of vitamin B12, our body will start manifesting several deficiency symptoms
Key Findings from Preclinical Research Insights from Animal Studies While we always look to human trials for definitive answers, preclinical research offers a powerful window into how a compound works
A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy
For maintenance or prophylactic use (such as in a patient with short-gut syndrome who cannot absorb oral vitamins well), a common regimen is 1 mL IM once weekly
