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In addition, studies on single TCMs for the treatment of AMS are mainly based on Rhodiola rosea L

Overall, substantial evidence supports HPA axis hypofunction in ME/CFS, although findings remain heterogeneous and the underlying mechanisms are not yet fully understood

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In SLE, mitochondrial dysfunction contributes to oxidative stress, altered apoptosis, mtDNA mutations, and impaired immune complex clearance, aggravating the loss of self-tolerance