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In the skin, for instance, they are crucial for the migration and development of epithelial cells and stimulate cell division

Pit-1 is mainly expressed in the pituitary somatotrophs, but it has also notably been demonstrated to be expressed in extrapituitary tissues

Di Lorenzo R, Forgione F, Bernardi A, Sacchi A, Laneri S, Greco G

At the cis-Golgi, GlcNAc-1-phosphotransferase (GNPT) transfers GlcNAc-1 phosphate from UDP-GlcNAc to specific mannose residues on the high mannose glycan chains of lysosomal enzymes, following which an uncovering enzyme (UCE) removes GlcNAc, forming an M6P monoester