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If you experience side effects from B12 supplementation, these can be reported to the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)

Although conceptual and functional overlap exists, this distinction is important because the two categories are subject to different regulatory pathways and evidentiary requirements

The animal literature largely used systemic routes (intraperitoneal), and the results were consistent regardless of injection location

[12] [13] Their side effects are well documented and generally mild (headache, flushing, nasal congestion, dyspepsia)