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K., Szeleszczuk, ., Gubica, T., Zieliska-Pisklak, M., Bethanis, K., Christoforides, E., Dudek, M

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Nature 445 , 661665 (2007)

Other FDA-approved drugs, including donepezil, galantamine, rivastigmine, and memantine, have demonstrated cognitive benefits but are frequently associated with gastrointestinal disturbances, dizziness, agitation, and, in some cases, severe hepatotoxicity, as observed with tacrine (Marucci et al., 2021

Strategies aimed at restoring antioxidant homeostasis and limiting inflammatory oxidative stress may therefore warrant further investigation as approaches to delay onset or slow disease progression