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1999 (PMID 10234025)

And I tell you, it's the great-How much time did you take off of it

After reconstitution, keep refrigerated (about 2-8 C), protect from light, and use within a few weeks

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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin