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They can be detected in the brain, biofluids [urine, cerebrospinal fluid (CSF), and blood], and, more recently, in stool samples (Tarallo et al., 2021)

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1 Approximately one-third to 40% of a typical proteome is a metalloprotein, 2 and cells must ensure that the metalloproteome is metalated with integrity, defined by binding of the cognate or native metal under all growth conditions, yet is sufficiently plastic or adaptable, so as to effectively respond to metal limitation while avoiding metal toxicity

Anxiety-like behaviors Analysis of exploratory behavior in the open field test demonstrated significant alterations in both inner area time and vertical activity across the experimental groups