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doi: 10.1038/s41467-024-53380-5 87 MajumdarRBarchiBTurlapatiSAGagneMMinochaRLongSet al

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The Role of the Liver in Glutathione Synthesis and Distribution Synthesis of GSH occurs in the cytoplasm in all cells in two subsequent ATP-dependent reactions catalyzed by glutamate-cysteine ligase and GSH synthetase, from where it is transported to other organelles and extracellular space [8,19]