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The American biochemist Loren Pickart discovered it in 1973 when he observed that liver tissue from older patients exhibited improved protein synthesis in the presence of plasma from younger donors

PMID 23729217

Sorafenib-induced ferroptosis and cell death is aided by the downregulation of complexin II (CPLX2) and haloperidol (a sigma receptor 1 antagonist) (96, 97)

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Winter SC, Szabo-Aczel S, Curry CJ, Hutchinson HT, Hogue R, Shug A: Plasma carnitine deficiency