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One-Component Systems One-component systems for peptide cyclization make use of at least one unnatural or modified amino acid residue, along with a complimentary functional group located on the side-chain of another amino acid that may or may not be proteinogenic (e.g., Cys, Lys)

reported that curcumin induces apoptosis and cell cycle arrest in the G2/M phase in tumor cells, in part by reducing HDAC4 expression and inhibiting its activity (Lee et al., 2011)

Caffeic acid is a common phenolic chemical found in a wide variety of plants

304 Its positively charged amino acids interact electrostatically with the phosphate backbone of NADs, enabling the delivery of RNA and DNA

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