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Supplemental material Intervention and placebo The active substance of vitamin B 12 given in the study is 2 mL mecobalamin (5 mg/ml), administered intramuscularly.25 Placebo substance is 2 mL sodium chloride (9 mg/ml), isotonic solution for parenteral use (Baxter) intramuscularly.26 All participants are informed that their urine may turn red, which may occur during mecobalamin injections

Understanding B12's neurological importance helps contextualise concerns about its potential effects on anxiety

Nature Reviews Endocrinology, 13(4), 220-231

Bacteriostatic Water 3ML Bacteriostatic Water is sterile, non-pyrogenic water infused with 0.9% benzyl alcohol as a preservative

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