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Glucose uptake in T cells undergoing activation is strictly correlated to GLUT1, identifying the transporter as a key determinant in glucose utilization (36, 37)

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Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial

This is probably due to the fact that network activity results from the synchronized activation of all excitatory synapses at the same time, and as a consequence, modulations are detected mainly by changes in the frequency of burst occurrence