We assessed ferroptosis using convergent readouts including iron dysregulation (transferrin receptor 1 [TfR1], ferritin heavy chain 1 [FTH1], labile and mitochondrial iron [Fe 2+ ]), lipid peroxidation (C11-BODIPY and 4-hydroxynonenal [4-HNE]), glutathione peroxidase 4 (GPX4) suppression, and pharmacologic inhibition by ferrostatin 1 (Fer-1) in primary enteric neurons, murine myenteric plexuses, and human networks of myenteric ganglia (nhMPG)
86.7% (13 of 15) in EPG of 1,0004,999
Neurocognitive peptides are short chains of amino acids that act as signaling molecules and specifically target the brain and nervous system
In an experimental mouse model of stroke, the administration of TMG reduced infarct size, ameliorated neurological impairments, and enhanced clinical outcomes through regulating the expression of pro-inflammatory and anti-inflammatory cytokines [110]
Small, 4(6), 746-750