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Concomitant short-chain fatty acid deficits, particularly butyrate loss from Akkermansia muciniphila depletion, impair BBB claudin-5 expression and neuronal mitochondrial biogenesis [57, 58]

The evidence consists of mechanistic research on each compound individually, small observational studies from anti-aging clinics, and patient-reported outcomes from practitioners using the protocol off-label

To evaluate the potential of different pathways geared toward improving GSH synthesis, several DNA-mediated integrative expression vectors pGAPh-gsh2gsh1, pGAPg-pro1gshB or pGAPg-proBgshB harbouring different pathway genes were constructed

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The Lancet 402(10413):1627-1635, 2023