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Finally, because this retrospective study used samples collected over multiple years, the effects of long-term storage and pre-analytical variability cannot be entirely excluded, particularly for labile lipid mediators such as eicosanoids, despite standardized processing and storage at -80 C
However, T4 must be converted into the metabolically active T3 thyroid hormone
Furthermore, in human reviews 3 of muscle protein metabolism, activation of IGF-1/Akt/mTOR signaling directly correlated with higher protein synthesis rates and improved muscle density, particularly in response to resistance training and nutrient intake
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