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The fact that numerous attempts in this direction have been made, and yet thee is no substitute for tobacco and no de-nicotinized tobacco in general use, is itself a sufficient answer to the question

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Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations

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These days, the infamous cheese-filter cigarette is remembered only in isolated corners of the internet, finding itself ranked among other bizarre inventions