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Keywords Methaqualone (Quaalude) Toxicology Source: a non-barbiturate sedative-hypnotic Mechanism of Action: a sedative hypnotic that stimulates the actions of GABA on GABA A receptors by binding to a transmembrane site distinctly different from the binding sites for benzodiazepines and barbiturates (Hammer et al, 2015) Symptoms: resembles barbiturate poisoning ataxia : produces pronounced motor problems & is known as wallbanger because of this phenomenon Can lead to severe muscular hypertonicity and seizures Treatment: no diuresis diazepam for severe muscular tone or seizures strongly consider phenytoin as an anticonvulsant because barbiturates potentiate the effect of methaqualone Notes: Methaqualone (quaaludes) were popular recreational drugs in the 1960's and 70's, especially in disco clubs
Anisomycin has the potential to induce human ovarian cancer stem cell ferroptosis by influencing glutathione metabolism and autophagy signal transduction pathways
Cancer Immunol Res
Choose Glutathione if: You want to support detoxification
Rf = 0.15 (AcOEt/cyclohexane, 7:3)
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