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Critically, the predominant sporadic form of ALS (~90% of cases) lacks defined genetic targets, complicating patient stratification and demanding the development of therapies targeting convergent pathological pathways (15, 16)

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Similarly, previous work simulating the conditions of Enceladus has demonstrated that the methanogenic archaeon, Methanothermococcus okinawensis , can produce CH 4 when grown in an optimal growth medium, at 5 MPa (Taubner et al., 2018)

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