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The use of MRS for analysis of brain metabolites in addition to blood biomarker investigations will provide greater understanding of the pathophysiology of this patient cohort and their response to intervention

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Regular health checkups, laboratory tests, and professional guidance related to the treatment for high vitamin B12 are key to maintaining a healthy balance and ensuring the early detection of any hidden conditions

To select for transfectants, 6 h post transfection, 2 nM WR99210 was added to the culture and later increased, usually after 34 weeks (after the appearance of transfectants), to 5 nM