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These compounds ( 14 , 15 , 16 , 18 , and 19 ), were a series of related metabolites that eluted as a series of peaks, each differing in m/z value by +31.97 when analyzed by MS

Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death

The function of GSH in hepatocytes has been investigated by pharmacological inhibition or genetic ablation of the glutamate-cysteine ligase (GCL), the rate-limiting and regulatory enzyme in GSH biosynthesis

,, Although there are several inhibitors of the cystine/glutamate transporter other than sulfasalazine, these drugs have limitations of low bioavailability and low selectivity to of the cystine/glutamate transporter in vivo

However, it is not suitable for everyone