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Interestingly, intracellular A accumulation and impaired proteasome function can be reversed by the ubiquitin E3 ligase parkin (Rosen et al., 2010)
Bruno, B
Thereby, BPC 157 effects on counteraction of ketamine-cognition dysfunction, social withdrawal, and anhedonia, and exerted additional anxiolytic effect, in addition to well-suited models (i.e., cognitive dysfunction (novel object recognition test)) [207,208,209], social withdrawal [210,211], anhedonia (sucrose test) [212,213], anxiogenic effect (open field test) [214,215], can have a particular background
Ans - Yes, you can
It has indeed been demonstrated that p300/CBP transcriptional co-activator proteins (two central players in coordinating and integrating multiple signal dependent events with the transcription apparatus [215, 216]) bind to NRF2 in response to OS induced by arsenite and acetylate several Lys residues within the Neh1, the DNA binding region of NRF2, stabilizing it, increasing protein abundance, and promoting NRF2 nuclear localization [146, 214, 217] (Fig
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