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The vape refill is pre-filled with a flavoured e-liquid that, when vaporised, delivers a realistic smoking sensation without the harmful tar and second-hand smoke associated with traditional cigarettes

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Osteoarthritis, which has been postulated as a long-term consequence of JHM and related altered joint biomechanics [69], was instead only a sporadic finding in our cEDS cohort as well as marfanoid habitus