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Factors governing subcellular distribution of desnutrin/ATGL, including mechanisms by which the cytoplasmic enzyme accesses its substrate and potential translocation to the lipid droplet, remain to be determined

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Furthermore, it was shown that senolytic vaccination improved normal and pathological phenotypes associated with aging, and extended the male lifespan of progeroid mice (79)

[38] In canine in vivo studies castration, which significantly reduced androgen levels but left estrogen levels unchanged, caused significant atrophy of the prostate

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