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Description

Protein Sci 5(1):5261

Ligand discovery for orphan peptides typically begins with a structurally constrained pharmacophore that can be mapped against candidate receptor binding pockets

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50 Studies of esketamine, approved by the FDA for treatment of refractory depression at doses ranging from 0.25 to 0.5 mg/kg, suggest use of single or repeated doses is unlikely to cause urothelial toxicity