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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

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The differentially expressed proteins revealed that mainly the respirasome, mitochondrial ribosome, hydrogen peroxide and glutathione metabolic processes are responsible for the effect exerted by the double combination on Be(2)C cells ( Figure 7A )

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