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Therefore, it seems that other mechanisms should be considered in designing anti-EpCAM antibodies [143]

But clinical trial comparisons across different studies carry significant caveats

doi: 10.3389/fimmu.2021.718359

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Decreased levels of TNF- and IL-6 indicate that NNMT inhibition not only modulates metabolism but also improves the inflammatory microenvironment, a key component in metabolic disease development and insulin resistance