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107 Similarly, ER stress, a hallmark of metabolic diseases, places additional demand on the UPS through the activation of the UPR

Although iron metabolism abnormalities and lipid peroxidation mediated by ferroptosis are important mechanisms that regulate kidney diseases and ferroptosis-related defense mechanisms, including the system Xc-/GSH/GPX4 pathway, the mitochondrial pathway and the FSP1/CoQ 10 /NAD(P)H pathway, the specific details and crosstalk among these pathways are still not well understood

Furthermore, a recent review that assessed several trials reached the conclusion that supplementation of any vitamins before or during pregnancy does not prevent the occurrence of miscarriages [164]

Mol Asp Med

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