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Budzynska B, Wnorowski A, Kaszubska K, Biala G, Kruk-Somka M, Kurzepa J, Boguszewska-Czubara A (2018) Acute MDMA and nicotine co-administration: behavioral effects and oxidative stress processes in mice

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Liver IGF-1-deficient mice show a reduction of around 75% in circulating IGF-1 levels and as a consequence due to the lack of negative feedback, these mice have about a fourfold increase in GH production